Room 1020 Emerging Tech. Building (ETB)
Texas A&M Health Science Center
Microarrays, yeast two-hybrid screens, next generation sequencing, imaging, and mass spectrometry are just a few examples of technologies that produce large amounts of data. The ever-increasing flood of biomedical data creates a pressing need to develop tools and algorithms that facilitate comprehension, construction of models for homeostasis, development and disease processes, and the creation of well-informed hypotheses. Moreover, typical biomedical investigators do not have the background or resources to leverage complex or arcane computational tools, so the proposed solutions for grappling with biomedical data must also be highly accessible. StarNet (http://vanburenlab.tamhsc.edu/starnet2.html) and Cognoscente (http://vanburenlab.tamhsc.edu/cognoscente.html) were designed to address these needs. StarNet is a web-based query and
visualization tool for correlation data derived from pre-defined sets of microarray expression data in the public domain. Cognoscente is a web-based query and visualization tool for documented biomolecular interactions,
including physical interactions such as protein-protein, protein-DNA, and protein-RNA interactions, and non-physical genetic interactions. These tools complement each other insofar as StarNet provides visualization and novel analyses of data, whereas Cognoscente provides visualization and novel analysis of documented knowledge. This seminar will present the rationale and utility of these tools, and discuss a trajectory for their continued development.
Bio: Dr. Vincent VanBuren is currently an Assistant Professor in the Department of Medical Physiology at the Texas A&M Health Science Center College of Medicine. He earned his PhD in Molecular Biology from Lehigh University in 2002, where he created computational models of microtubule assembly and disassembly processes. From 2002 to 2006 he was a postdoctoral fellow working on bioinformatics for developmental biology and regenerative medicine at the National Institute on Aging in Baltimore. In 2006 Dr. VanBuren was appointed as an Assistant Professor in the Department of Systems Biology and Translational Medicine (now Medical Physiology). Dr. VanBuren has published collaborative research for biostatistics and bioinformatics using omics data across diverse fields, including bioengineering and simulation, regenerative medicine and stem
cell biology, cardiovascular research, bone biology, cancer biology, podiatry, and biomarker discovery. In 2011, Dr. VanBuren was elected as a Fellow of the American Heart Association.
Host: Dr. Hu