Krishnendu Chakrabarty, Duke University
Room 1034 ETB
Advances in droplet-based “digital” microfluidics have led to the emergence of biochip devices for automating laboratory procedures in biochemistry and molecular biology. As a result, non-traditional biomedical applications and markets (e.g., high-throughout DNA sequencing, portable and point-of-care clinical diagnostics, protein crystallization for drug discovery), and fundamentally new uses are opening up for ICs and systems. This lecture will first provide an overview of market drivers such as immunoassays, DNA sequencing, clinical chemistry, etc., and electrowetting-based digital microfludic biochips. The audience will next learn about design automation, design-for-testability, and reconfiguration aspects of digital microfluidic biochips. Synthesis tools will be described to map assay protocols from the lab bench to a droplet-based microfluidic platform and generate an optimized schedule of bioassay operations, the binding of assay operations to functional units, and the layout and droplet-flow paths for the biochip. The role of the digital microfluidic platform as a “programmable and reconfigurable processor” for biochemical applications will be highlighted. Finally, the speaker will describe dynamic adaptation of bioassays through cyberphysical system integration sensor-driven on-chip error recovery.
Bio: Krishnendu Chakrabarty received the B. Tech. degree from the Indian Institute of Technology, Kharagpur, in 1990, and the M.S.E. and Ph.D. degrees from the University of Michigan, Ann Arbor, in 1992 and 1995, respectively. He is now the William H. Younger Distinguished Professor of Engineering in the Department of Professor of Electrical and Computer Engineering and Professor of Computer Science at Duke University. In addition, he serves as the Executive Director of Graduate Studies in Electrical and Computer Engineering. Prof. Chakrabarty is a recipient of the National Science Foundation Early Faculty (CAREER) award, the Office of Naval Research Young Investigator award, the Humboldt Research Award from the Alexander von Humboldt Foundation, Germany, and 10 best paper awards at major IEEE conferences.
Prof. Chakrabarty’s current research projects include: testing and design-for-testability of integrated circuits; digital microfluidics, biochips, and cyberphysical systems; optimization of digital print and enterprise systems.
Host: Dr. Khatri